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Objective: Microleakage continues to be a main reason for failure of root canal therapy, where the challenge has been to achieve an adequate seal between the internal tooth structure and the main obturation material, gutta-percha. The Resilon/Epiphany (R/E) system uses a new obturation material that bonds chemically with the internal tooth structure, thereby decreasing the possibility of microleakage. The purpose of this study was to compare dye leakage in root canals filled with R/E and those in which gutta percha was used.