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Focal epithelial hyperplasia (FEH) is a rare benign lesion caused by human papillomavirussubtype 13 or 32. The condition occurs in numerous populations and ethnic groups.A higher incidence in close communities and among family members indicates infectiouspathogenesis. A 21-year-old woman with FEH is described, in whom the lesions hadpersisted for 10 years. A literature review is also presented, with emphasis on manifestationsin the oral mucosa and histopathological features.